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12/100PY), respectively. In the fixed effects regression model, the hazard of dental treatment was substantially lower after sealant placement on a tooth, with time-averaged hazard ratio HR=0.23 (95% CI 0.21-0.25, P.001) versus before sealant. The largest effect was in the first year after sealant placement (HR=0.13, 95% CI 0.11-0.14), which decreased over time (HR=0.50, 0.59 and 0.74 in years 2, 3 and 4, respectively), and was not statistically significant in later years. This study demonstrates that permanent first molar sealant pla
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