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4%) and 23 of 40 perforations closed completely in the FGF-2 treatment group (57.5%), value = .36. Pure tone averages and word recognition scores were not statistically significantly different between study groups post-treatment. After initial complete closure, re-perforation occurred in seven FGF-2 treated patients and two placebo patients making the effective final closure rate 40% for FGF and 57% for placebo, respectively. No statistically significant difference in tympanic membrane perforation closure rate was found between the FGF
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