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A total of 269 patients met study criteria. The mean BMD z rating (-0.55, 95% confidence interval -0.68, -0.42) had been less than expected (P  0.0001), and also the prevalence of reduced BMD z score (≤-2. was higher than expected (8.5%, 95% self-confidence period 5.2%-11.9%, P  0.0001). In multivariable regression designs, BMD z ratings were use of proton pump inhibitor and a restrictive eradication diet, but not swallowed steroid use. Bigger prospective researches are essenti