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This is the first report of a DNA polymerase that impacts mitochondrial nucleoid distribution. © 2020. Published by The Company of Biologists Ltd.Excessive reactive oxygen species (ROS) can cause oxidative stress and consequently cell injury contributing to a wide range of diseases. Addressing the critical gaps in our understanding of the adaptive molecular events downstream ROS provocation holds promise for the identification of druggable metabolic vulnerabilities. Here, we unveil a direct molecular link between the activity of two est
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