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87±7.22years (mean±standard deviation) and 21 healthy subjects (age 46.0±12.6years) from July 2017 to July 2018. MS patients showed a lower DCs density when compared with healthy subjects (p0.05). Moreover, we found a direct correlation (r0.48, p0.05) between DCs density and ongoing disease-modifying therapy. IVCM was able to show a difference in corneal DCs density between MS patients and healthy subjects, providing an insight to the underlying changes of the clinical manifestations of MS. Further studies are needed to provide