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Meanwhile, the feasibility of the plans is assured by integrating constraints handling techniques in the MOEA. Leveraging historical weather data and realistic mission settings, we analyze the performance of the planner for different scenarios and conclude that it is capable of determining overall good solutions under different conditions.Repressor element-1 (RE-1) or neural restrictive silencer element (NRSE) bound with a zinc finger transcription repressor, RE-1 silencing transcription factor (REST, also known as neural restrictive sil