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The role of e-health is increasing worldwide. We surveyed the use of e-health in a large-scale population-based study, involving a representative sample of the Norwegian population aged above 40 years. Two-thirds of the health professionals had used search engines, apps, social media or video services for health purposes - while this was the case for approximately half of the non-health professionals.As the COVID-19 pandemic evolves, the accompanying infodemic is being amplified through social media and has challenged effective response.