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0% vs. 64.1%; p  .01), followed by pneumococcal pneumonia (PNA) (13% vs. 9.4%; p  .01). After adjusting for confounders, patients with HFrEF had higher odds of having diagnosis of IV (adjusted [aOR], 1.42; p  .01) and PNA (aOR, 1.27; p  .01). Patients with VPDs and HFrEF had significantly higher odds of mortality (aOR, 1.76; p  .01), LOS, respiratory failure requiring mechanical ventilation, and mechanical ventilation for less than 96 h. Influenza and PNA were the most common VPDs admitted to the hospital in patients