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Advantages of methadone in paediatric customers with advanced cancer had been its security and effectiveness as a first-choice opioid, accessibility as a liquid formulation and its infrequent dosage requirements. Methadone is neither advised nor justified to be used as an anti-cancer medication and its part as an anti-cancer agent is a misconception. Numerous instructions had been suggested after 2008 to address methadone security. Most of them emphasized on avoidance of cardiac arrhythmia and