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Medications and Therapy For ADHD Combining medication and therapy can help to manage ADHD. The medication treats the brain while therapy helps patients cope and learn skills. Stimulants, such as lisdexamfetamine and methylphenidate, increase levels of two chemical substances in the brain that transmit messages between cells. This improves attention, impulse control and motivation. Stimulants may cause negative side effects, like sleeplessness, weight loss and an increase in blood pressure
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