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Therefore, it's important to recognize efficient treatment to ease discomfort. In this work, we selected Forsythoside B (F, a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, to evaluate its result in modulating inflammatory pain induced by full Freund's adjuvant (CFA) and also the involved components. We unearthed that FB could attenuate inflammatory pain triggered by CFA injection and exert anti-anxiety effects. In more detail, proinflammatory cytokines, comprising IL-6