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Does ADHD Medication Work? When someone receives a prescription for ADHD medication, they frequently think about whether the medication will be effective and how long it will last. Here are some easy answers. Stimulants adjust brain chemicals that transmit messages about activity and attention. These include norepinephrine and dopamine. They are considered the first-line treatment option for adults suffering from ADHD. 1. Stimulants Stimulants are the most commonly used medications to manage ADHD. The