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In addition, an emerging therapy strategy targeting mitochondria, namely, metabolic resuscitation, seems promising. The current review briefly introduces the mechanism of SIMD, highlights how mitochondrial dysfunction contributes to SIMD, and discusses the role of metabolic resuscitation in the treatment of SIMD.Phytoplankton play important roles in marine ecosystems and have major impacts on the global biogeochemical cycles, yet the knowledge of the processes for oceanic environments controlling the phytoplankton dynamics stil