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Conclusion This article focuses on novel approaches such as lipid-based formulations and nano- or microparticles as treatment strategies to minimize side effects by using carriers viz. liposome, noisome, transferosome, hydrogel, microemulsion, and nanoparticle formulations for intraarticular, topical, and even oral delivery.2019 novel coronavirus (2019-nCoV), also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19 virus, is a member of the family Coronaviridae, which is responsible for the current pandemic