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Stimulants Are the Most Effective ADHD Medication For Adults The most common prescription medication prescribed by health professionals to treat ADHD in adults is stimulants. They work by increasing the levels of certain neurotransmitters (chemicals) in your brain. This improves attention and reduces impulsivity. Antidepressants like Strattera (atomoxetine) and Zyban/Wellbutrin (bupropion) can also aid in controlling ADHD. They