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Ivabradine exerts a few pleiotropic results, including an antiremodeling property, that are separate of its principal heart-rate-reducing effects. Its suppressive results on cardiac remodeling are shown in pet models of cardiac remodeling and heart failure. It reduces myocardial fibrosis, apoptosis, infection, and oxidative stress as well as increases autophagy in the pets. It modulates myocardial calcium homeostasis, neurohumoral systems, and power metab