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Most Effective ADHD Medication For Adults The majority of adults report that medication can help them concentrate, feel calmer and improve their relationships. Other treatment methods, such as psychotherapy, can also be helped by medications. Adults suffering from ADHD are more likely to benefit from stimulants. They include amphetamine and methylphenidate compounds. Adults may take short-acting medicines often throughout the day or long-acting medications that start slow and last for between 3