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dently associated with the increased risk of usage of CRRT (OR = 2.77, 95%CI was 2.18-3.51), mechanical ventilation 5 days (OR = 2.45, 95%CI was 2.21-2.72), the length of ICU stay 5 days (OR = 2.29, 95%CI was 2.10-2.49), and total hospitalization time 14 days (OR = 2.28, 95%CI was 2.08-2.49), all P 0.001. Retrospective analysis of large sample shows that MLR elevation is an independent risk factor for 30-day mortality, usage of CRRT, prolonged mechanical ventilation time, prolonged hospitalization, prolonged length o