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13 per 0.1 increase, 95% confidence interval1.04, 1.23), independent of arterial oxygen saturation, was associated with mortality. Current rest ventilator management for children receiving V-V ECMO primarily relies on conventional mechanical ventilation with moderate amounts of PIP, PEEP, and FiO . Further study on the relationship between FiO and mortality should be pursued. Current rest ventilator management for children receiving V-V ECMO primarily relies on conventional mechanical ventilation with moderate amounts of PIP, PEEP, and