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Possible adverse effects of the plasma were recorded during the pretreatment including associated pain, heat, erythema, and edema. The VAS score of the treated side was statistically lower (5.1±2.1) compared with the nontreated side (6.3±1.9), with a mean difference of 1.3 (95% confidence interval [CI], 0.6-1.9; P.0001). No severe adverse event was reported, and all the disturbing sensations and symptoms (pain, heat, and edema) were evaluated as mild with no mean score surpassing 4.0. Plasma pretreatment of 5minut