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99 (0.93-1.05). This association was modified by sex an increased risk was observed in men 1.20 (1.02-1.42), with a decreased risk in women 0.91 (0.84-0.99). The quality of the evidence ranged from low to moderate. Pooled observational cohort studies suggest that the absence of associations reported between regular physical activity and AF risk in previous general population studies and their aggregate analyses could be driven by a sex-specific difference in the associations - an increased risk in men and a decreased risk in women.Syst