https://www.selleckchem.com/pr....oducts/bezafibrate.h
Arenes with β-stereogenic centers are important substructures in pharmaceuticals and natural products. Their synthesis traditionally involves two separate and individually challenging steps enantioselective synthesis of a chiral main-group organometallic complex and subsequent cross-coupling with an aryl electrophile. We describe the development of asymmetric anti-Markovnikov hydroarylation of 1,1-disubstituted olefins by dual palladium and copper hydride catalysis as a convenient and significantly more general alternative. This rea
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