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Previous studies have reported that oxidative stress increases intracellular Zn concentrations and induces cytotoxicity. However, no studies have investigated whether oxidative stress induces such changes in periodontal tissue cells. In the present study, we investigated the effect of oxidative stress on intracellular Zn concentration in periodontium constituent cells and its potential relationship with periodontal disease. We analyzed changes in intracellular Zn concentrations in human gingival epithelial (epi4) cells treated with hydr
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