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The percentages were recorded accordingly with their respective histological grades. The results were analysed statistically. The results of the present study demonstrated higher mean values of stathmin in tissues with OSCC (2.5 compared to leukoplakia (2.11) and normal tissues (0.0 with a high level of statistical significance (0.0001). There is also an increase in the percentage levels of stathmin with increase in the histological grade of differentiation in OSCC as well as leukoplakia. The present study found a statistical correlation between