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Although colonoscopy is routinely performed for the management of lower gastrointestinal bleeding (LGI, the quality of evidence supporting its use is poor and its yield for active bleeding or malignancy is low in practice. We conducted a retrospective analysis of all adult patients who underwent colonoscopies for LGIB at our hospital system between January 1, 2015, and December 31, 2019. A statistical model was built on a cohort of 5195 cases using multiple logistic regressions to predict the detection of various colonoscopy findings