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0117), demonstrating a role for JAK1 in modulating STAT in granulosa cells. This study implicates a conserved role for JAK/STAT signalling in human ovary development, warranting further investigation of this pathway in human granulosa cell function. In the UK, juvenile idiopathic arthritis is the most common inflammatory disorder in childhood, affecting 10  100,000 children and young people aged  16 years each year, with a population prevalence of around 1  1000. Corticosteroids are commonly used to treat juvenile idiopathic arthrit