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This paper describes the detailed statistical analysis plan for the evaluation of primary and secondary endpoints of the ProPAC-COVID study. Enrolment of patients to the ProPAC-COVID study is still ongoing. The purpose of this paper is to provide primary publication of study results to prevent selective reporting of outcomes, data-driven analysis, and to increase transparency. ClinicalTrials.gov NCT04322396 . Registered on 26 March 2020. ClinicalTrials.gov NCT04322396 . Registered on 26 March 2020. The use of warfarin in patients with