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The revealed differences can be important in further studies to explain why various Tpm isoforms interact uniquely with actin filaments, thus playing an important role in the organization and dynamics of the cytoskeleton.This paper aims to provide a preliminary assessment of polyurethane adhesive applicability as an alternative to conventional cement-based adhesives used to fix thermal insulation materials to substrates concerning mineral wool-based external thermal insulation composite systems. Currently, polyurethane adhesives are on