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How Does ADHD Medication Work? The drugs reduce ADHD symptoms by increasing levels Dopamine and Noradrenaline. These are chemicals that transmit messages between brain cells. The most commonly prescribed stimulants are methylphenidate and Atomoxetine. Finding the right dose and dosage will require a lot of trial and trial and. Open, honest communication with your doctor is key. Stimulants The stimulant drugs prescribed to treat ADHD increase levels of the hormo