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Finding the Best ADHD Medication For Adults Stimulants like methylphenidate or amphetamine (Vyvanse) rapidly work to balance brain chemicals. These medications can cause loss of appetite, sleep issues, weight changes and tics in some people. Atomoxetine and certain antidepressants (like bupropion) are non-stimulant medications that work slowly to assist those suffering from ADHD symptoms. They increase a chemical in