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Medications and Therapy For ADHD A combination of medication and therapy can help manage ADHD symptoms. The medication treats the brain while therapy helps people cope and improve their skills. Stimulants like lisdexamfetamine and methylphenidate, increase levels of two chemical substances in the brain that pass messages between cells. This improves the level of attention, impulse control, and motivation. Stimulants can cause side effects such as weight loss, d