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Finding the Best Medication For ADHD Stimulants are the most frequently prescribed medications for ADHD. They include amphetamines and methylphenidates. Short-acting stimulants are effective in less than one hour and need to be taken multiple times per day. Long-acting stimulants last up to 16 hour and are taken at least once a day. Your doctor might prescribe antidepressants or other types of medication "off-label" to treat ADHD symptoms. These are drugs approved to treat other conditions
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