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The side effect profile of anti-PD-1 antibodies appears to be favorable compared to chemotherapy. In this way, PD-1 inhibitors are expected to become the new gold-standard treatment for patients with locally advanced and metastatic cSCC. © 2020 Wiley Periodicals, LLC.Cerium dioxide nanoparticles (CeO2 NPs) with a high value of ζ-potential (≥ 30 mV) have been synthesized in reverse microemulsions and they are able to form the high-stable aqueous suspension without any additional stabilizers. It has been shown that the interaction of such