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S1P2 antagonist attenuated the phosphorylation of JNK into the abdominal aorta compared to vehicle (p＜0.05). In HUVEC, S1P promoted inflammatory molecule expression such as MCP-1 and VCAM-1 p＜0.001), which was attenuated by S1P2 antagonist or a JNK inhibitor (p＜0.01). S1P2 antagonist also inhibited S1P-induced JNK phosphorylation in HUVEC (p＜0.05).Our results recommended that an S1P2 antagonist attenuates endothelial dysfunction and prevents ather
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