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eria diagnosis given for each disease, we proposed the term Oral Epithelial Atypia of Unknown Significance to characterize cellular and dysplastic changes possibly related to chronic inflammation but without a true certainty of its evolution. This term could encourage the clinician to perform a careful follow up of cases of REA/D and also readdress the focus of research regarding oral carcinogenesis. Finally, if all microscopic findings linked to inflammation are diagnosed as REA/D, may lead to underestimation of the potential of inflamm