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g well-controlled and sequence-regulated polymers. It provides the first collective structure-metathesis reactivity relationships for CPEs in the context of polymer chemistry and an understanding of the interactions between the catalyst and the substituents of appended ring-opened CPEs. It may become clear from this Account that the exploration of strained cycles in polymer chemistry can be quite fruitful in discovering new chemistry and accessing new types of polymer materials.Although extensive research is being done to combat SARS-CoV-2, we a