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Meanwhile, we observed positive correlations between the frequencies of IL-27 lymphocytes and MG-ADL score (P=0.030, r=0.527). By contrast, no significant correlation was found between IL and 27 serum levels and MG-ADL score (P=0.099, r=-0.414). IL-27 may play an important role in the pathological process in AChR-MG patients, and the frequencies of IL-27-producing (CD3 IL-27 ) T cells may be a potential biomarker for predicting the severity of AChR-MG. IL-27 may play an important role in the pathological process in AChR-MG patients, an