https://pkcpathway.com/alloste....ric-unsafe-effects-o
Intracerebroventricular injection of an enzymatic glutamate scavenger system, glutamic-pyruvic transmine (GPT, 1 μM), significantly increased the PSA in Sham rats, suggesting that extracelluar buildup of glutamate might be at fault of impaired glutamatergic transmission, that was influenced by the uptake by Glt-1 in astrocytes. We revealed that hippocampal Glt-1 expression amount in the L-CORT rats was much higher compared to Sham and H-CORT rats. In a gradient neuron-astrocyte coculture, we d
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