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Serplulimab plus chemotherapy administered every 2 days considerably improved PFS and OS in patients with previously untreated, PD-L1-positive advanced level ESCC, with a manageable safety profile. This research is subscribed with ClinicalTrials.gov ( NCT03958890 ).The mechanistic target of rapamycin complex 1 (mTORC1) controls cellular growth in response to amino acid and blood sugar levels. Nevertheless, exactly how mTORC1 senses glucose access to manage variou