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Stimulant Vs Non Stimulant ADHD Medication The most common prescription medication used by healthcare providers to treat ADHD is stimulants. These drugs focus on specific brain chemicals, like dopamine and norepinephrine, to enhance symptoms of impulsivity and inattention. Nonstimulant drugs are an alternative to treatment for patients who aren't responding to stimulants. They also have fewer negative effects. They target various neurotransmitters or receptors. Stimulant medications are a great option for some, but not all.