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Does ADHD Medication Work? When someone is given a prescription for ADHD medication, they often think about whether the medication will work and how long it will last. Here are some simple answers. Stimulants adjust brain chemicals that send messages regarding attention and activity. Dopamine, norepinephrine, and other brain chemicals are among them. They are often considered to be the first-line treatment option for adults with ADHD. 1. Stimulants Stimulants are commonly used to treat ADHD. They alter the activity of ne