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Four PIWI proteins are found is expressed in people. How many researches centering on the roles of piRNAs and PIWI proteins in the field of disease is increasing. Oral, esophageal, and gastric types of cancer are considered as essential factors behind demise. PIWI proteins and piRNAs are recommended is involved in the pathogenesis of these diseases. Thus, studying these particles a very good idea for finding brand new therapeutics. As it is shown that currently used biomarkers for these cancers have