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n in close proximity to the intercalated disks and some areas along the longitudinal axis in the MR hearts. Conclusions These results indicate that LV dysfunction in response to severe MR is a form of maladaptive eccentric cardiomyocyte hypertrophy and outline the link between cell polarity regulation and spatial localization protein synthesis as a pathway for directional cardiomyocyte growth.With regard to life sciences, it is important to understand biological functions such as metabolic reactions at the cellular level. Time-of-flight se
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