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This pathway mayprovide therapeutic targets for bone-related diseases, as well as functionas abiomarkerfor bone homeostasis. This article is protected by copyright. All rights reserved.During examination of cases of chilblains in children and adolescents, we identified four patients who also showed skin lesions similar to erythema multiforme (EM). They had no other known triggers for EM. One of them had a positive PCR for SARS-CoV-2, while the other 3 were negative. Skin biopsies from two patients showed features not typical of EM, such
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