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We also describe some examples of the aforementioned approaches and the relevant discoveries they made to understand the domestication of the studied taxa.Background and Aims Familial hypercholesterolemia (FH) is one of the major risk factor for the progression of atherosclerosis and coronary artery disease. This study focused on identifying the dysregulated molecular pathways and core genes that are differentially regulated in FH and to identify the possible genetic factors and potential underlying mechanisms that increase the risk to