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Does ADHD Medication Work? When someone is given ADHD medication, they worry about how long the treatment will last and if it works. Here are some simple answers. Stimulants adjust brain chemicals that send messages about activity and attention. These include norepinephrine and dopamine. They are often considered to be the first-line treatment option for adults with ADHD. 1. Stimulants Stimulants are frequently used to treat ADHD. They alter the activity neurotransmitters in the