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How Does Medication For ADHD Work? Many people find that their symptoms improve when they take a medication. But finding the right drug and dose is a process that requires patience, time and communication with your GP or a specialist. The medicines that treat ADHD adjust the levels of chemical messengers within the brain. Drugs that stimulate, like methylphenidate help reduce impulsivity and hyperactivity and increase focus. Atomoxetine and guanfacine, both non-stimulant medications that improve the behavior of children and decrease tics.