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To evaluate the efficacy and safety of transition from premixed and intensive insulin to twice-daily insulin degludec/aspart (IDegAsp) co-formulation in patients with type 2 diabetes mellitus. In this 12-week study, patients receiving twice-daily premixed insulin therapy in group 1 ( = 55) were switched to twice-daily IDegAsp. In group 2 ( = 6, patients on intensive insulin therapy were switched to IDegAsp injected twice a day. Inter- and intragroup comparisons were made. A total of 115 patients were included in the study. There was