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Stimulants Are the Most Effective ADHD Medication For Adults Stimulants are the most common prescription medications that healthcare professionals utilize to treat ADHD in adults. They work by increasing levels of certain chemicals (neurotransmitters) in your brain to improve concentration and decrease the risk of impulsivity. Antidepressants like Strattera (atomoxetine) and Wellbutrin/Zyban (bupropion) can also aid in controlling ADHD. They increase levels of norepinephrine in your brain. Stimulants Stimulants are the most commonly prescribed ADHD medication for