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This multi-marker shows significant advantages in the precision of diagnosis and prognosis compared to albuminuria. Furthermore, many of its peptide markers map the molecular pathophysiology of DN. Clinical urinary proteome analysis shows great benefits and is already an appropriate tool for the early detection of incipient DN. Clinical urinary proteome analysis shows great benefits and is already an appropriate tool for the early detection of incipient DN. Despite ongoing development, mortality in sepsis remains considerable. Various